Corrected p-value on cortex

Description 

Based random field theory, multiple comparisons can be done. The p-value after multiple comparisons correction is usually referred as the corrected p-value. It computes p-values on triangular meshes that is topologically equivalent to a sphere. It has been applied to both the human cortex and the human hippocampus surface.

MATLAB Codes (MATLAB 6.1. implementation)

This is modified from Keith Worsley's original fMRIstat package. 

• surf_tstat_threshold.m computes the t random field based thresholding corresponding to a given corrected p-value.

The corrected p-value can be computed on the following sample cortical surface. 

[tri,coord,nbr,normal]=mni_getmesh('outersurface.obj');

trisurf(tri, coord(1,:),coord(2,:),coord(3,:));

• mni_getmesh.m loading polygonal mesh data into MATLAB.
• Outsurface.obj sample cortical surface mesh (MNI mesh).

Documentation 

• Chung, M.K., Robbins,S., Dalton, K.M., Davidson, Alexander, A.L., R.J., Evans, A.C. 2005. Cortical thickness analysis in autism via heat kernel smoothing. NeuroImage 25:1256-1265.
• Chung, M.K., Robbins, S., Evans, A.C. 2005. Unified statistical approach to cortical thickness analysis. Information Processing in Medical Imaging (IPMI). Lecture Notes in Computer Science. Springer. (acceptance rate < 26%). in press.
• Worsley, K.J., Marrett, S., Neelin, P., Vandal, A.C., Friston, K.J., and Evans, A.C. 1996. A unified statistical approach for determining significant signals in images of cerebral activation. Human Brain Mapping, 4:58-73.
• Shen, L., Saykin, A., McHugh, T., West, J., Rabin, L., Wishart, H., Chung, M.K., Makedon, F. 2005. Morphometric analysis of 3D surfaces: appliction to hippocampal shape in mild cognitive impairment. 6th International conference on computer vision, pattern recognition and image processing in conjunction with 8th joint cocnference on information sciences (CVPRIP). 2005.
• Pantazis, D., Leachy, R.M., Nichols, T.E., Styner, M. 2004. Statistical surface-based morphometry using a non-parametric approach.  IEEE International Symposium on Biomedical Imaging (ISBI).

Last update 05/9/2005.