Intestinal neoplasia in the <i>Apc-Min</i> Mouse: Independence from the
microbial and natural killer (<i>beige </i> Locus) status
Intestinal neoplasia in the Apc-Min Mouse: Independence from the
microbial and natural killer (beige Locus) status
W.F. Dove, L. Clipson, K.A. Gould, C. Luongo, D.J. Marshall,
A.R. Moser,
M.A. Newton , and R.F. Jacoby.
Cancer Research 57, 812-814, 1997.
Abstract:
We have tested the hypothesis that enteric bacteria are necessary for formation
of intestinal adenomas in C57BL/6-Apc-Min/+ mouse. Germfree mice developed
two-fold fewer adenomas than convential controls in the medial small intestine
(7.3 vs 14.9; p<.003), but there were no significant differences in the rest
of the intestinal tract. We conclude that microbial status does not strongly
alter the adenoma phenotype in this mouse model of familial adenomatous
polyposis. In parallel, we have found that C57BL/6-Apc-Min/+ mice
mutated at the beige locus that controls natural killer activity
are also unaltered in adenoma multiplicity.
Key words: APC; colon cancer; germfree; mice; natural resistance