### Description

Dynamic topological data analysis (dynamic-TDA) focuses on analyzing dynamically changing time series data using persistent homology. The method can be applicable to wide variety of dynamically changing data including resting-state functional magnetic resonance images (rs-fMRI) and dynamically changing correlation matrices. The basic terminology and concept are introduced in [1]. If you use data or codes in this page, please reference Songdechakraiwut et al. 2020.**Codes below explained in section 1)-3) are packaged as**

**song.2020.simulation3.zip**

**.**Section 1)-3) perform the transposition test topological distance on the two-groups setting. Simply run run_simulation_v3.m.

### 1) Modular network simulation

This is the basic statistical model given as Study 2
in the simulation study in Songdechakraiwut
et al. 2020.
Function random_modular_graph.m
will generate a modular network. The input
parameters are as follows.mu = 1; %mean

sigma = .25; %standard deviation

nNode1 = 50; %number of nodes in network G

nModule1 = 2; %number of modules of graph G

nNode2 = 60; %number of nodes in network P

nModule2 = 3; %number of modules of graph P

nModule2 = 3; %number of modules of graph P

G = random_modular_graph(nNode1, nModule1, p, mu, sigma); %network with 2 modules

P = random_modular_graph(nNode2, nModule2, p, mu, sigma); %network with 3 modules

figure; subplot(1,2,1); imagesc(G); colorbar

subplot(1,2,2); imagesc(P); colorbar

Figure 1. Simulated networks with 2 modules and 3 modules. The parameter p controls the probability of connection within the module.

The graphs can be displayed by thresholding the complete graph at 0.5 and displaying them as binary graphs:

Gbinary = adj2bin(G,0.5);

Ggraph = graph(Gbinary)

### 2) Wasserstein distance on graphs

The Wasserstein distance between two graphs of
different size and topology is first introduced in Songdechakraiwut
et al. 2020.
WS_distance.m computes the sum of 0D and 1D
Wasserstein
distance between
two weighted
adjacency matrices
G and P. >WS_distance(G,P)

ans =

19.9532

WS_distancemat.m computes the topological loss between groups and within groups and represent it as a loss matrix. We will generate two groups. The first group g1 will have 4 networks with 2 modules. The second group g2 will have 6 networks with 3 modules. Since they are topologically different,

nGroup1 = 4;

nGroup2 = 6;

g1 = cell(nGroup1, 1);

g2 = cell(nGroup2, 1);

for k = 1:nGroup1

g1{k} = random_modular_graph(nNode1, nModule1, p, mu, sigma);

end

for k = 1:nGroup2

g2{k} = random_modular_graph(nNode2, nModule2, p, mu, sigma);

end

lossMtx = WS_distancemat('top', g1, g2, []);

figure; imagesc(lossMtx); colorbar

Figure 2. The topological loss within groups is lower than the topological loss between groups.

### 3) Topological inference on Wasserstein distance
via transpositions

The transposition test on the ratio statistic of
thee between-group loss over within-group loss
is computed as follows (study 2 in Songdechakraiwut
et al. 2020).
An additional weblink for the transposition test is
given here.observed = WS_ratio(lossMtx, nGroup1, nGroup2, @between_over_within)

nTrans = 200000; % number of transpositions

permNo = 500; % intermix random permutation every 'permNo' transpositions

[transStat, ~] =WS_transpostions(lossMtx, nGroup1, nGroup2, nTrans, permNo, @between_over_within);

transPval = online_pvalues(transStat, observed);

pval = transPval(end)

### Reference

[1] Songdechakraiwut, T. Chung, M.K. 2020 Dynamic topological data analysis for functional brain signals,

*IEEE International Symposium on*Biomedical Imaging (ISBI) Workshop 1-4 Shorter abstract

[2] Songdechakraiwut, T. Chung, M.K. 2020 Topological learning for brain networks, arXiv: 2012.00675

[3] Chung, M.K., Huang, S.-G., Songdechakraiwut, T., Carroll, I.C., Goldsmith, H.H. 2020 Statistical analysis of dynamic functional brain networks in twins

*, arXiv 1911.02731*MATLAB

[4] Kulkarni, A.P., Chung, M.K., Bendlin, B.B., Prabhakaran, V. 2020 Investigating heritability across resting state brain networks via heat kernel smoothing on persistence diagrams,

*IEEE International Symposium on*Biomedical Imaging (ISBI) workshop 1-4.

[5] Huang, S.G., Chung, M.K., Qiu, A, ADN Initiative 2020 Revisiting convolutional neural network on graphs with polynomial approximations of Laplace-Beltrami spectral filtering, arXiv:2010.1326

[6] Huang, S.G., Chung, M.K., Qiu, A, ADN Initiative 2020 Fast mesh data augmentation via Chebyshev polynomial of spectral filtering, arXiv:2010.02811

[7] Chung, M.K., Xie, L., Huang, S.-G., Wang, Y., Yan, J., Shen, L. 2019. Rapid Acceleration of the permutation test via transpositions,

*International Workshop on Connectomics in NeuroImaging*, Lecture Notes in Computer Science 11848:42-53. A different version

*arXiv:1812.06696*